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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
26.36
Human Site:
Y461
Identified Species:
41.43
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
Y461
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Chimpanzee
Pan troglodytes
XP_509205
601
66595
Y461
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
Y461
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Dog
Lupus familis
XP_538273
601
66656
Y461
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
Y459
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Rat
Rattus norvegicus
Q4V8A3
586
65492
L447
Y
F
I
N
S
K
G
L
P
R
Y
C
S
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
N424
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
Chicken
Gallus gallus
Q5ZIU3
526
59419
R408
I
L
N
G
G
R
S
R
R
G
K
L
R
G
P
Frog
Xenopus laevis
NP_001088793
567
63329
Y428
N
F
I
N
S
K
G
Y
P
R
Y
C
T
V
T
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
H448
N
F
I
S
S
K
G
H
P
R
Y
C
T
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
Y515
S
F
F
S
P
K
G
Y
P
R
Y
C
T
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
L676
Q
L
A
L
I
I
E
L
L
G
M
P
P
P
K
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
Q432
N
F
I
N
S
K
G
Q
P
R
Y
C
T
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
A349
H
E
N
L
E
H
L
A
M
M
E
R
V
L
G
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
H619
S
S
S
S
T
Q
K
H
R
M
K
T
I
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
100
66.6
N.A.
6.6
0
86.6
86.6
N.A.
73.3
N.A.
0
80
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
13.3
6.6
100
100
N.A.
80
N.A.
0
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
7
0
7
0
0
0
7
0
0
7
7
% E
% Phe:
0
67
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
7
7
0
67
0
7
20
0
0
0
7
14
% G
% His:
7
0
0
0
0
7
0
14
0
0
0
0
0
0
0
% H
% Ile:
7
0
27
0
7
7
0
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
0
67
7
0
0
0
14
0
0
0
7
% K
% Leu:
0
14
0
14
0
0
14
14
7
0
0
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
7
14
7
0
0
0
0
% M
% Asn:
54
0
14
20
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
0
67
0
0
7
7
7
7
% P
% Gln:
7
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
7
14
67
7
7
14
7
7
% R
% Ser:
20
7
7
60
60
0
7
0
0
0
0
7
7
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
7
60
0
60
% T
% Val:
0
0
34
0
7
7
0
0
0
0
0
0
7
67
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
47
0
0
67
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _